Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries
نویسندگان
چکیده
منابع مشابه
Mustard Gas Induced Ocular Injuries
1 Mustard gas is a lipophilic, highly cytotoxic agent that rapidly penetrates tissue, and the eye is one of the organs mostly affected,[1] but skin, respiratory, gastrointestinal, and renal systems as well as the bone marrow may also be affected.[2] Mustard gas related ocular injuries can be divided into immediate, chronic, and delayed‐onset phases. Acute manifestations of varying degrees, incl...
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Sulphur mustard is a vesicant (blistering agent), which produces chemical burns with widespread blistering. It was used extensively as a chemical warfare agent in the First World War, and has allegedly been employed in a number of conflicts since then, most recently by Iraq against Iran (1984-1987). The potential further use of mustard in military conflicts and by terrorists remains a significa...
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Lung neutrophilia is common to a variety of lung diseases. The production of reactive oxygen and nitrogen species during neutrophil oxidative burst has been associated with protein and DNA damage. Myeloperoxidase (MPO) is an enzyme stored in the azurophilic granula of neutrophils. It is important in host defense because it generates the reactive oxidant hypochlorous acid and has been described ...
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Subjects with neutrophil myeloperoxidase (MPO) deficiency have been rarely reported. In part this may be due to the lack of a simple screening technique that would detect them. With the routine use of a cytochemical leukocyte differential counter that employs MPO stains, over a 40-mo a period 8 unrelated probands with partial MPO-deficiency and one with complete deficiency were identified. Fami...
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The functional properties of granulocytes in a diabetic patient deficient in myeloperoxidase (MPO) were compared with those of granulocytes in healthy subjects. The granulocytes of this patient had normal phagocytic activity. The microbicidal activity of the granulocytes was partially diminished with regard to Staphylococcus aureus and was almost nil with regard to Candida albicans. Fungicidal ...
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ژورنال
عنوان ژورنال: Toxicology
سال: 2014
ISSN: 0300-483X
DOI: 10.1016/j.tox.2014.02.013